The de novo DNA methyltransferase DNMT3A in development and cancer

被引：75

作者：

Chen, Bi-Feng ^{[1
]}

Chan, Wai-Yee ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Chinese Univ Hong Kong Shandong Univ Joint Lab Re, Sch Biomed Sci, Shenzhen Res Inst, Hong Kong, Hong Kong, Peoples R China

来源：

EPIGENETICS | 2014年 / 9卷 / 05期

关键词：

cancer; development; DNA methylation; DNMT3A; epigenetics; ACUTE MYELOID-LEUKEMIA; GERM-CELL DEVELOPMENT; PWWP DOMAIN; METHYLATION ACTIVITY; DYNAMIC EXPRESSION; GENE DNMT3A; LYSINE; 36; MUTATIONS; 3A; FAMILY;

D O I：

10.4161/epi.28324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation, one of the best-characterized epigenetic modifications, plays essential roles in development, aging and diseases. The de novo DNA methyltransferase DNMT3A is responsible for the establishment of de novo genomic DNA methylation patterns and, as such, involved in normal development as well as in many diseases including cancer. In recent years, our understanding of this important protein has made significant progress, which was facilitated by stunning development in the analysis of the DNA methylome of multiple organs and cell types. In this review, recent developments in the characterization of DNMT3A were discussed with special emphasis on the roles of DNMT3A in development and cancer.

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收藏

页码：669 / 677

页数：9

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