Palladium-Catalyzed Domino Synthesis of 4-Amino-3-acyl-2-naphthols via Isocyanide Chemoselective Insertion

被引：13

作者：

Chen, Zhong ^{[1
]}

Duan, Hua-Qing ^{[1
]}

Jiang, Xiao ^{[1
]}

Zhu, Yong-Ming ^{[1
]}

Ji, Shun-Jun ^{[2
]}

Yang, Shi-Lin ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 16期

关键词：

OXIDATIVE ANNULATION; ACTIVATION; PHENANTHRIDINES; CARBOXAMIDATION; ISOCOUMARINS;

D O I：

10.1021/acs.joc.5b01269

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient strategy for the synthesis of sterically hindered 4-amino-3-acyl-2-naphthols through a palladium-catalyzed coupling reaction involving isocyanide chemselective insertion and domino isomerization has been developed. The methodology, which is in accordance with the principle of "atom and step economy", efficiently constructs 4-amino-3-acyl-2-naphthols in moderate to good yields.

引用

页码：8183 / 8188

页数：6

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