MicroRNAs: Key players in carcinogenesis and novel therapeutic targets

被引：108
|
作者：
Mirnezami, A. H. F. [1 ]
Pickard, K. [2 ]
Zhang, L. [2 ]
Primrose, J. N. [1 ]
Packham, G. [2 ]
机构：
[1] Southampton Gen Hosp, Level F Ctr Block, Univ Surg Unit, Southampton SO16 6YD, Hants, England
[2] Univ Southampton, Canc Sci Div, Southampton, Hants, England
来源：
EJSO | 2009年 / 35卷 / 04期
关键词：
MicroRNA; Molecular profiling; Cancer; Clinical utility; HUMAN LUNG CANCERS; GENE-EXPRESSION; BREAST-CANCER; SMALL RNAS; ANTISENSE OLIGONUCLEOTIDES; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; IN-VIVO; PROSTATE; GROWTH;
D O I：
10.1016/j.ejso.2008.06.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype. The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：339 / 347
页数：9
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