MicroRNAs: Key players in carcinogenesis and novel therapeutic targets

被引：108
|
作者：
Mirnezami, A. H. F. [1 ]
Pickard, K. [2 ]
Zhang, L. [2 ]
Primrose, J. N. [1 ]
Packham, G. [2 ]
机构：
[1] Southampton Gen Hosp, Level F Ctr Block, Univ Surg Unit, Southampton SO16 6YD, Hants, England
[2] Univ Southampton, Canc Sci Div, Southampton, Hants, England
来源：
EJSO | 2009年 / 35卷 / 04期
关键词：
MicroRNA; Molecular profiling; Cancer; Clinical utility; HUMAN LUNG CANCERS; GENE-EXPRESSION; BREAST-CANCER; SMALL RNAS; ANTISENSE OLIGONUCLEOTIDES; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; IN-VIVO; PROSTATE; GROWTH;
D O I：
10.1016/j.ejso.2008.06.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype. The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：339 / 347
页数：9
相关论文
共 50 条
  • [1] MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets
    Hussen, Bashdar Mahmud
    Abdullah, Sara Tharwat
    Rasul, Mohammed Fatih
    Salihi, Abbas
    Ghafouri-Fard, Soudeh
    Hidayat, Hazha Jamal
    Taheri, Mohammad
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [2] microRNAs: Key Players in Hematopoiesis
    Raghuwanshi, Sanjeev
    Karnati, Hanuma Kumar
    Sarvothaman, Shilpa
    Gutti, Usha
    Saladi, Raja Gopal Venakata
    Tummala, Prathibha Reddy
    Gutti, Ravi Kumar
    MICRORNA: BASIC SCIENCE: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE, 2015, 887 : 171 - 211
  • [3] microRNAs in heart disease: putative novel therapeutic targets?
    Condorelli, Gianluigi
    Latronico, Michael V. G.
    Dorn, Gerald W., II
    EUROPEAN HEART JOURNAL, 2010, 31 (06) : 649 - 658B
  • [4] MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis
    Vannini, Ivan
    Fanini, Francesca
    Fabbri, Muller
    CLINICAL BIOCHEMISTRY, 2013, 46 (10-11) : 918 - 925
  • [5] MicroRNAs as new therapeutic targets and tools in cancer
    Gandellini, Paolo
    Profumo, Valentina
    Folini, Marco
    Zaffaroni, Nadia
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2011, 15 (03) : 265 - 279
  • [6] MicroRNAs as therapeutic targets in chemoresistance
    Garofalo, Michela
    Croce, Carlo M.
    DRUG RESISTANCE UPDATES, 2013, 16 (3-5) : 47 - 59
  • [7] MicroRNAs: key players of taxane resistance and their therapeutic potential in human cancers
    Cui, Shi-Yun
    Wang, Rui
    Chen, Long-Bang
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2013, 17 (10) : 1207 - 1217
  • [8] MicroRNAs as therapeutic targets and their potential applications in cancer therapy
    Cho, William C. S.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (08) : 747 - 759
  • [9] MicroRNAs: Potentially important regulators for schistosome development and therapeutic targets against schistosomiasis
    Cheng, Guofeng
    Jin, Youxin
    PARASITOLOGY, 2012, 139 (05) : 669 - 679
  • [10] MicroRNAs as Therapeutic Targets in Nasopharyngeal Carcinoma
    Wang, Sumei
    Claret, Francois-Xavier
    Wu, Wanyin
    FRONTIERS IN ONCOLOGY, 2019, 9
12345