Self-regulating ubiquitin ligases

被引：1

作者：

Hill, Spencer ^{[1
]}

Kleiger, Gary ^{[1
]}

机构：

[1] Univ Nevada, Dept Chem & Biochem, Las Vegas, NV 89154 USA

来源：

EMBO JOURNAL | 2017年 / 36卷 / 04期

关键词：

PROTEIN LIGASE; DOMAINS;

D O I：

10.15252/embj.201696154

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Occasional auto-modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto-ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation.

引用

页码：392 / 393

页数：2

共 12 条

[1] Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases [J].

Attali, Ilan ;

Tobelaim, William Sam ;

Persaud, Avinash ;

Motamedchaboki, Khatereh ;

Simpson-Lavy, Kobi J. ;

Mashahreh, Bayan ;

Levin-Kravets, Olga ;

Keren-Kaplan, Tal ;

Pilzer, Inbar ;

Kupiec, Martin ;

Wiener, Reuven ;

Wolf, Dieter A. ;

Rotin, Daniela ;

Prag, Gali .

EMBO JOURNAL, 2017, 36 (04) :425-440

[2] RING Domain E3 Ubiquitin Ligases [J].

Deshaies, Raymond J. ;

Joazeiro, Claudio A. P. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 :399-434

[3] Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis [J].

Dunn, R ;

Hicke, L .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (02) :421-435

[4] Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress [J].

Fang, Nancy N. ;

Chan, Gerard T. ;

Zhu, Mang ;

Comyn, Sophie A. ;

Persaud, Avinash ;

Deshaies, Raymond J. ;

Rotin, Daniela ;

Gsponer, Joerg ;

Mayor, Thibault .

NATURE CELL BIOLOGY, 2014, 16 (12) :1227-U225

[5] Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 [J].

Kamadurai, Hari B. ;

Qiu, Yu ;

Deng, Alan ;

Harrison, Joseph S. ;

MacDonald, Chris ;

Actis, Marcelo ;

Rodrigues, Patrick ;

Miller, Darcie J. ;

Souphron, Judith ;

Lewis, Steven M. ;

Kurinov, Igor ;

Fujii, Naoaki ;

Hammel, Michal ;

Piper, Robert ;

Kuhlman, Brian ;

Schulman, Brenda A. .

ELIFE, 2013, 2

[6] The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme [J].

Kee, Y ;

Lyon, N ;

Huibregtse, JM .

EMBO JOURNAL, 2005, 24 (13) :2414-2424

[7] Regulation of catalytic activities of HECT ubiquitin ligases [J].

Kee, Younghoon ;

Huibregtse, Jon M. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 354 (02) :329-333

[8] Perilous journey: a tour of the ubiquitin-proteasome system [J].

Kleiger, Gary ;

Mayor, Thibault .

TRENDS IN CELL BIOLOGY, 2014, 24 (06) :352-359

[9] Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome [J].

Lyapina, S ;

Cope, G ;

Shevchenko, A ;

Serino, G ;

Tsuge, T ;

Zhou, CS ;

Wolf, DA ;

Wei, N ;

Shevchenko, A ;

Deshaies, RJ .

SCIENCE, 2001, 292 (5520) :1382-1385

[10] Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation [J].

Saha, Anjanabha ;

Deshaies, Raymond J. .

MOLECULAR CELL, 2008, 32 (01) :21-31

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