Increased serum concentrations of monokine induced by interferon-γ/CXCL9 and interferon-γ-inducible protein-10/CXCL-10 in Sydenham's chorea patients

被引：32
作者：
Teixeira, AL
Cardoso, F
Souza, ALS
Teixeira, MM
机构：
[1] Univ Fed Minas Gerais, Fac Med, Movement Disorders Clin, Minas Gerais, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunopharmacol, Minas Gerais, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 150卷 / 1-2期
关键词：
Sydenham's chorea; cytokines; chemokines; CXCL9; CXCL10;
D O I：
10.1016/j.jneuroim.2004.01.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：157 / 162
页数：6
相关论文
共 33 条
[1]   Brain SPECT imaging in Sydenham's chorea [J].
Barsottini, OGP ;
Ferraz, HB ;
Seviliano, MM ;
Barbieri, A .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2002, 35 (04) :431-436
[2]  
BRONZE MS, 1993, J IMMUNOL, V151, P2820
[3]   Treatment of Sydenham chorea with corticosteroids [J].
Cardoso, F ;
Maia, D ;
Cunningham, MCQS ;
Valença, G .
MOVEMENT DISORDERS, 2003, 18 (11) :1374-1377
[4]   Chorea in fifty consecutive patients with rheumatic fever [J].
Cardoso, F ;
Eduardo, C ;
Silva, AP ;
Mota, CCC .
MOVEMENT DISORDERS, 1997, 12 (05) :701-703
[5]  
Cardoso F, 1999, MOVEMENT DISORD, V14, P805, DOI 10.1002/1531-8257(199909)14:5<805::AID-MDS1013>3.0.CO
[6]  
2-P
[7]  
CARDOSO F, 2002, PARKINSONS DIS MOVEM, P584
[8]   CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? [J].
Church, AJ ;
Dale, RC ;
Cardoso, F ;
Candler, PM ;
Chapman, MD ;
Allen, ML ;
Klein, NJ ;
Lees, AJ ;
Giovannoni, G .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 136 (1-2) :149-153
[9]   Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea [J].
Church, AJ ;
Cardoso, F ;
Dale, RC ;
Lees, AJ ;
Thompson, EJ ;
Giovannoni, G .
NEUROLOGY, 2002, 59 (02) :227-231
[10]  
COLONY HS, 1956, NEUROLOGY, V59, P227
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