Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy

被引：124

作者：

Helleberg, Marie ^{[1
]}

Niemann, Carsten Utoft ^{[2
]}

Moestrup, Kasper Sommerlund ^{[1
]}

Kirk, Ole ^{[1
]}

Lebech, Anne-Mette ^{[1
]}

Lane, Clifford ^{[3
]}

Lundgren, Jens ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark

[2] Copenhagen Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark

[3] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

COVID-19; SARS-CoV-2; remdesivir; immunocompromised; case report; INFECTION;

D O I：

10.1093/infdis/jiaa446

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antiviral drug remdesivir has been shown clinically effective for treatment of COVID-19. We here demonstrate suppressive but not curative effect of remdesivir in an immunocompromised patient. A man in his fifties treated with chemoimmunotherapy for chronic lymphocytic leukemia experienced a 9-week course of COVID-19 with high fever and severe viral pneumonia. During two 10-day courses of remdesivir starting 24 and 45 days after fever onset, pneumonia and spiking fevers remitted, but relapsed after discontinuation. Kinetics of temperature, C-reactive protein, and lymphocyte counts mirrored the remitting/relapsing SARS-CoV-2 infection. Combination therapy or longer treatment duration may be needed in immunocompromised patients.

引用

页码：1103 / 1107

页数：5

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