Role of microRNAs and long non-coding RNAs in glucocorticoid signaling (Review)

被引：6

作者：

Pierouli, Katerina ^{[1
]}

Papageorgiou, Louis ^{[1
]}

Mitsis, Thanasis ^{[1
]}

Papakonstantinou, Eleni ^{[1
]}

Diakou, Io ^{[1
]}

Leptidis, Stefanos ^{[1
]}

Sigala, Markezina ^{[1
]}

Dragoumani, Konstantina ^{[1
]}

Spandidos, Demetrios A. ^{[2
]}

Bacopoulou, Flora ^{[3
,4
]}

Chrousos, George P. ^{[3
,4
]}

Goulielmos, George N. ^{[5
]}

Eliopoulos, Elias ^{[1
]}

Vlachakis, Dimitrios ^{[1
,3
,4
,6
]}

机构：

[1] Agr Univ Athens, Sch Appl Biol & Biotechnol, Dept Biotechnol, Lab Genet, Athens 11855, Greece

[2] Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71003, Greece

[3] Natl & Kapodistrian Univ Athens, Univ Res Inst, Aghia SophiaChildrens Hosp, Maternal & Child Hlth & Precis Med, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Aghia SophiaChildrens Hosp, UNESCO Chair Adolescent Hlth Care, Athens 11527, Greece

[5] Univ Crete, Sch Med, Dept Internal Med, Sect Mol Pathol & Human Genet, Iraklion 71003, Greece

[6] Biomed Res Fdn, Acad Athens, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2022年 / 50卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

glucocorticoid signaling; miRNAs; lncRNAs; GR; endogenous glucocorticoids; stress response system; ACUTE LYMPHOBLASTIC-LEUKEMIA; LIGAND-BINDING DOMAIN; INDUCED CELL-DEATH; C MEMBER 1; MESSENGER-RNA; GROWTH-ARREST; DOWN-REGULATION; HPA AXIS; RECEPTOR; GENE;

D O I：

10.3892/ijmm.2022.5203

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The synthesis and release of glucocorticoids in living organisms are related to their response to unfavorable stressful conditions in order to maintain homeostatic functions and survive. One such hormone in humans is cortisol, which is produced by the hypothalamic-pituitary-adrenal cortex axis and binds with the glucocorticoid receptor (GR) following its secretion. GR controls a number of distinct gene networks. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), regulate the expression and function of GR, having a considerable impact on various biological processes and treatment approaches for numerous disorders. In the present review, the GR pathways and signaling as part of the stress response system are discussed. A detailed report on the role of miRNAs and lncRNAs in glucocorticoid signaling is also presented.

引用

页数：15

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