Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

被引：105

作者：

McWilliams, Robert R. ^{[1
]}

Maisonneuve, Patrick ^{[2
]}

Bamlet, William R. ^{[3
]}

Petersen, Gloria M. ^{[4
]}

Li, Donghui ^{[5
]}

Risch, Harvey A. ^{[6
]}

Yu, Herbert ^{[7
]}

Fontham, Elizabeth T. H. ^{[8
]}

Luckett, Brian ^{[9
]}

Bosetti, Cristina ^{[10
]}

Negri, Eva ^{[10
]}

La Vecchia, Carlo ^{[10
,11
]}

Talamini, Renato ^{[12
]}

de Mesquita, H. Bas Bueno ^{[13
,14
,15
]}

Bracci, Paige ^{[16
]}

Gallinger, Steven ^{[17
]}

Neale, Rachel E. ^{[18
]}

Lowenfels, Albert B. ^{[19
]}

机构：

[1] Mayo Clin, Dept Oncol, 200 First St Southwest, Rochester, MN 55905 USA

[2] European Inst Oncol, Div Epidemiol & Biostat, Milan, Italy

[3] Mayo Clin, Div Biostat, Rochester, MN USA

[4] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[5] UT MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA

[6] Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA

[7] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA

[8] Louisiana State Univ, Sch Publ Hlth, New Orleans, LA USA

[9] Tulane Sch Publ Hlth, New Orleans, LA USA

[10] Univ Milan, Dept Epidemiol, IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy

[11] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[12] IRCCS, Ctr Riferimento Oncol, SOC Epidemiol & Biostat, Aviano, PN, Italy

[13] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[14] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[15] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[16] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[17] Univ Toronto, Div Gen Surg, Toronto, ON, Canada

[18] QIMR Berghofer Med Res Inst, Canc & Populat Studies Grp, Brisbane, Qld, Australia

[19] New York Med Coll, Dept Surg, Dept Family Med, Valhalla, NY 10595 USA

来源：

PANCREAS | 2016年 / 45卷 / 02期

基金：

美国国家卫生研究院;

关键词：

pancreatic cancer; alcohol; early onset; very early onset; smoking; obesity; BODY-MASS INDEX; AGE-OF-ONSET; POOLED-ANALYSIS; CIGARETTE-SMOKING; DIABETES-MELLITUS; ALCOHOL; COHORT; METAANALYSIS; TOBACCO; CONSUMPTION;

D O I：

10.1097/MPA.0000000000000392

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose- and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

引用

页码：311 / 316

页数：6