Impact of Dissection after Drug-Coated Balloon Treatment of De Novo Coronary Lesions: Angiographic and Clinical Outcomes

被引：19

作者：

Hui, Lin ^{[1
,2
]}

Shin, Eun-Seok ^{[1
,3
]}

Jun, Eun Jung ^{[1
]}

Bhak, Youngjune ^{[4
]}

Garg, Scot ^{[5
]}

Kim, Tae-Hyun ^{[1
]}

Sohn, Chang-Bae ^{[1
]}

Choi, Byung Joo ^{[1
]}

Kun, Liu ^{[2
]}

Yuan, Song Lin ^{[1
]}

Zhi, Wang ^{[2
]}

Hao, Jiang ^{[2
]}

Shi Zhentao ^{[2
]}

Qiang, Tang ^{[2
]}

机构：

[1] Ulsan Med Ctr, Div Cardiol, Dept Internal Med, 13 Wolpyeong Ro 171beon Gil, Ulsan 44686, South Korea

[2] Peking Univ, Shougang Hosp, Dept Cardiol, Beijig 100144, Peoples R China

[3] Univ Ulsan, Ulsan Univ Hosp, Div Cardiol, Dept Internal Med,Coll Med, Ulsan, South Korea

[4] Ulsan Natl Inst Sci & Technol UNIST, Dept Biomed Engn, Coll Informat Bioconvergence Engn, Ulsan, South Korea

[5] East Lancashire Hosp NHS Trust, Blackburn, Lancs, England

来源：

YONSEI MEDICAL JOURNAL | 2020年 / 61卷 / 12期

关键词：

Balloon angioplasty; dissection; coronary heart disease; outcome research; ANGIOPLASTY; RESTENOSIS;

D O I：

10.3349/ymj.2020.61.12.1004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with a high risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections and subsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novo coronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) following DCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vessel failure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vessel thrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differences in LLL (90.8%) returning for angiography at 6 months (0.05 +/- 0.19 mm in non-dissection and 0.05 +/- 0.30 mm in dissection group, p= 0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariate analysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completely healed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associated with an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

引用

页码：1004 / 1012

页数：9