Stromal cell derived factor-1 (SDF-1) is a chemokine that plays a critical role in the homing of stem and progenitor cells, including endothelial progenitor cells (EPCs). However, little research has been undertaken to evaluate the roles of SDF-1 in the biological functions of EPCs and related signaling pathways. The present study aimed to investigate the biological functions of EPCs in response to SDF-1, as well as the underlying mechanisms. The effects of SDF-1 treatment on EPC proliferation, migration and tube formation were assessed by performing MTS, Transwell and in vitro tube formation assays, respectively. The phosphorylation status of Akt and ERK was evaluated by western blotting. The present results indicated that SDF-1 treatment enhanced EPC proliferation, migration and tube formation compared with the control group. Furthermore, SDF-1-induced EPC proliferation was significantly reduced following treatment with a C-X-C Motif Chemokine Receptor 4 antagonist (AMD3100), a PI3K inhibitor (LY294002) and the mitogen-activated protein kinase kinase inhibitor (MEK; PD98059). SDF-1-induced migration and angiogenesis were significantly suppressed by the PI3K inhibitor, but not the MEK inhibitor. Moreover, SDF-1 significantly increased the protein expression levels of phosphorylated (p)-Akt and p-ERK; however, SDF-1-induced effects on protein expression were suppressed by AMD3100, LY294002 and PD98059. Thus, SDF-1-induced EPC proliferation was mediated by activation of the Akt and ERK signaling pathways, whereas SDF-1-mediated EPC migration and tube formation only involved activation of the Akt signaling pathway.
机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Ahluwalia, Amrita
;
Jones, Michael K.
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机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Jones, Michael K.
;
Matysiak-Budnik, Tamara
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机构:
CHU Nantes, Serv Hepatogastroenterol, F-44035 Nantes 01, FranceVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Matysiak-Budnik, Tamara
;
Tarnawski, Andrzej S.
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机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
机构:
Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Ammendola, Michele
;
Leporini, Christian
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机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Leporini, Christian
;
Luposella, Maria
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机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Med & Surg Sci, Cardiovasc Dis Unit, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Luposella, Maria
;
Sacco, Rosario
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Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Sacco, Rosario
;
Sammarco, Giuseppe
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机构:
Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Sammarco, Giuseppe
;
Russo, Emilio
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机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Russo, Emilio
;
Patruno, Rosa
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机构:
Natl Canc Res Ctr Giovanni Paolo II, Intervent Radiol Unit, Integrated Sect Translat Med Oncol, Bari, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Patruno, Rosa
;
De Sarro, Giovambattista
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机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
De Sarro, Giovambattista
;
Ranieri, Girolamo
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机构:
Natl Canc Res Ctr Giovanni Paolo II, Intervent Radiol Unit, Integrated Sect Translat Med Oncol, Bari, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Ahluwalia, Amrita
;
Jones, Michael K.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Jones, Michael K.
;
Matysiak-Budnik, Tamara
论文数: 0引用数: 0
h-index: 0
机构:
CHU Nantes, Serv Hepatogastroenterol, F-44035 Nantes 01, FranceVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Matysiak-Budnik, Tamara
;
Tarnawski, Andrzej S.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
Southern Calif Inst Res & Educ, Long Beach, CA USAVet Affairs Long Beach Healthcare Syst, Long Beach, CA USA
机构:
Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Ammendola, Michele
;
Leporini, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Leporini, Christian
;
Luposella, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Med & Surg Sci, Cardiovasc Dis Unit, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Luposella, Maria
;
Sacco, Rosario
论文数: 0引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Sacco, Rosario
;
Sammarco, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Sammarco, Giuseppe
;
Russo, Emilio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Russo, Emilio
;
Patruno, Rosa
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Res Ctr Giovanni Paolo II, Intervent Radiol Unit, Integrated Sect Translat Med Oncol, Bari, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
Patruno, Rosa
;
De Sarro, Giovambattista
论文数: 0引用数: 0
h-index: 0
机构:
Univ Catanzaro Magna Graecia, Sch Med, Dept Hlth Sci, Clin Pharmacol & Pharmacovigilance Unit, I-88100 Catanzaro, Italy
Univ Catanzaro Magna Graecia, Sch Med, Pharmacovigilances Ctr Calabria Reg, I-88100 Catanzaro, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
De Sarro, Giovambattista
;
Ranieri, Girolamo
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Res Ctr Giovanni Paolo II, Intervent Radiol Unit, Integrated Sect Translat Med Oncol, Bari, ItalyMagna Graecia Univ Catanzaro, Sch Med, Clin Surg Unit, Dept Med & Surg Sci, I-88100 Catanzaro, Italy