Incidence and risk factors of subsequent osteoporotic fracture: a nationwide cohort study in South Korea

被引：19

作者：

Shim, Yoon-Bo ^{[1
]}

Park, Jae-A ^{[1
]}

Nam, Jin Hyun ^{[1
]}

Hong, Sung-Hyun ^{[1
]}

Kim, Ji Wan ^{[2
]}

Jeong, Jihae ^{[3
]}

Shin, Ju-Young ^{[1
,4
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, 2066 Seobu Ro, Suwon, Gyeong Gi Do, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthopaed Surg, Seoul, South Korea

[3] Amgen Korea, Seoul, South Korea

[4] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea

来源：

ARCHIVES OF OSTEOPOROSIS | 2020年 / 15卷 / 01期

关键词：

Epidemiology; Osteoporotic fracture; Subsequent fracture; Fracture risk factors; Incidence; MORTALITY;

D O I：

10.1007/s11657-020-00852-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study analyzed the incidence and risk factors of subsequent osteoporotic fractures in South Korea. The results showed that the incidence rate of subsequent fractures within 24 months was 10.23 per 100 person-years. Additionally, the index hip fracture site was a significant risk factor for a subsequent fracture. Purpose To identify and analyze the incidence and risk factors of subsequent osteoporotic fractures in South Korea. Methods This retrospective cohort study analyzed data from the National Health Insurance Review and Assessment claims database from 2012 to 2017. Men and women with osteoporosis, aged >= 50 years, with index fractures between July 1, 2014, and July 1, 2015, were included. The incidence rate of subsequent fractures was calculated by determining the number of second event within 2 years from the index fracture. To identify the risk factors for subsequent fractures, we applied the Cox proportional hazard model to estimate the hazard ratios (HRs). Results Of the 73,717 patients with osteoporotic fractures, 13,203 (17.91%) had a subsequent fracture. The incidence rate of subsequent fractures within 24 months was 10.23/100 person-years. The index fracture site was a significant risk factor for a subsequent fracture, with the hip showing the highest risk (HR, 7.51; 95% confidence interval [CI], 6.77-8.34), followed by the vertebra (HR, 1.99; 95% CI, 1.91-2.06). The risk of subsequent fractures increased with a higher Charlson Comorbidity Index (CCI) score (CCI score >= 5: HR, 1.79; 95% CI, 1.67-1.92). Conclusion The incidence rate of subsequent osteoporotic fractures in South Korea is similar or higher than that reported in the USA and Europe. A hip fracture within the prior 2 years, relative to other fracture sites, significantly increased the risk of subsequent fractures in osteoporosis patients. Patients who have these risk factors need closer disease management to prevent subsequent fractures.

引用

页数：7