Update on Immunohistochemistry for the Diagnosis of Lung Cancer

被引：106

作者：

Inamura, Kentaro ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Canc Inst, Div Pathol, Koto Ku, 3-8-31 Ariake, Tokyo 1358550, Japan

来源：

CANCERS | 2018年 / 10卷 / 03期

关键词：

immune checkpoint; immunostaining; INSM1; morphology; non-small cell lung carcinoma (NSCLC); pathology; thoracic tumor; small cell lung carcinoma (SCLC); tyrosine kinase; WHO classification; NUT MIDLINE CARCINOMA; GROWTH-FACTOR RECEPTOR; LIGAND; EXPRESSION; PREVIOUSLY TREATED PATIENTS; PD-L1; IMMUNOHISTOCHEMISTRY; CELL-CARCINOMA; OPEN-LABEL; ROS1; INTERNATIONAL-ASSOCIATION; BAP1;

D O I：

10.3390/cancers10030072

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunohistochemistry is a widely available technique that is less challenging and can provide clinically meaningful results quickly and cost-efficiently in comparison with other techniques. In addition, immunohistochemistry allows for the evaluation of cellular localization of proteins in the context of tumor structure. In an era of precision medicine, pathologists are required to classify lung cancer into specific subtypes and assess biomarkers relevant to molecular-targeted therapies. This review summarizes the hot topics of immunohistochemistry in lung cancer, including (i) adenocarcinoma vs squamous cell carcinoma; (ii) neuroendocrine markers; (iii) ALK, ROS1, and EGFR; (iv) PD-L1 (CD274); (v) lung carcinoma vs malignant mesothelioma; and (vi) NUT carcinoma. Major pitfalls in evaluating immunohistochemical results are also described.

引用

页数：15

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