DREADDs: novel tools for drug discovery and development

被引：70

作者：

Lee, Hyeong-Min

Giguere, Patrick M.

Roth, Bryan L. ^{[1
]}

机构：

[1] Univ N Carolina, Div Chem Biol & Med Chem, Chapel Hill Med Sch, Dept Pharmacol, Chapel Hill, NC 27514 USA

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 04期

关键词：

PROTEIN-COUPLED RECEPTORS; DESIGNED G(I)-COUPLED RECEPTOR; FUNCTIONAL SELECTIVITY; CONDITIONAL EXPRESSION; SEROTONIN RECEPTORS; SIGNAL-TRANSDUCTION; TRANSGENIC MICE; PATHWAYS; LIGANDS; TARGETS;

D O I：

10.1016/j.drudis.2013.10.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and orphan GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development.

引用

页码：469 / 473

页数：5

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