Docking Prediction of Amantadine in the Receptor Binding Domain of Spike Protein of SARS-CoV-2

被引：15

作者：

Baig, Abdul Mannan ^{[1
]}

Khaleeq, Areeba ^{[1
]}

Syeda, Hira ^{[2
]}

机构：

[1] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi 74800, Pakistan

[2] Mohammad Ali Jinnah Univ, Karachi 75400, Pakistan

来源：

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2020年 / 3卷 / 06期

关键词：

SARS-CoV-2; COVID-19; Wuhan coronavirus outbreak; viral pandemics; SARS virus; MERS virus; bat virus; zoonotic infections; biological agents; BSL 4. vaccine and antibody against SARS-CoV-2;

D O I：

10.1021/acsptsci.0c00172

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amantadine has recently been shown to improve patients with COVID-19. In addition to its known mechanism of actions, we performed docking prediction of this drug on the receptor-binding domain of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. We hypothesize that such interaction may possibly have contributed a role in the clinical improvements reported.

引用

页码：1430 / 1433

页数：4

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