Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors

被引：95

作者：

Zhou, Yue ^{[1
]}

Tan, Li-Li ^{[1
]}

Li, Qing-Lan ^{[1
]}

Qiu, Xi-Long ^{[2
]}

Qi, Ai-Di ^{[2
]}

Tao, Yanchun ^{[1
]}

Yang, Ying-Wei ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 11期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

acetylcholine; drug delivery; macrocyclic chemistry; mesoporous materials; silica nanoparticles; MESOPOROUS SILICA NANOPARTICLES; CONTROLLED DRUG-RELEASE; PARKINSONS-DISEASE; MOLECULES; BINDING; PSEUDOROTAXANES; NANOCONTAINERS; COMPLEXATION; RECOGNITION; SYSTEM;

D O I：

10.1002/chem.201304864

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene- or pillarene-based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof-of-concept study is far from a real-life application, it provides a possible route to treat diseases related to the central nervous system.

引用

页码：2998 / 3004

页数：7

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