Toxicity of zinc oxide nanoparticles on adult male Wistar rats

被引：102

作者：

Abbasalipourkabir, Roghayeh ^{[1
]}

Moradi, Hemen ^{[2
]}

Zarei, Sadegh ^{[3
]}

Asadi, Soheila ^{[1
]}

Salehzadeh, Aref ^{[4
]}

Ghafourikhosroshahi, Abolfazl ^{[5
]}

Mortazavi, Motahareh ^{[6
]}

Ziamajidi, Nasrin ^{[1
]}

机构：

[1] Hamadan Univ Med Sci, Sch Med, Dept Clin Biochem, Hamadan 65176, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran

[3] Yazd Univ Med Sci, Sch Med, Dept Clin Biochem, Yazd, Iran

[4] Hamadan Univ Med Sci, Sch Med, Dept Entomol & Toxicol, Hamadan 65176, Iran

[5] Hamadan Univ Med Sci, Sch Pharm, Dept Med Chem, Hamadan 65176, Iran

[6] Hamadan Univ Med Sci, Sch Med, Dept Anat Sci, Hamadan 65176, Iran

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2015年 / 84卷

关键词：

ZnO nanoparticles; Oxidative stress system; Liver enzyme; Sperm analysis; Histopathology; ZNO NANOPARTICLES; OXIDATIVE STRESS; DNA-DAMAGE; CELLS; CYTOTOXICITY; GENOTOXICITY; NANOMATERIALS; INDUCTION; APOPTOSIS; DELIVERY;

D O I：

10.1016/j.fct.2015.08.019

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four continuously received 50, 100, 150 and 200 mg/kg nZnO, respectively. Group five served as the control group. At the end of the study, the rats were sacrificed and histopathological study of the liver and renal tissue, sperm analysis, serum oxidative stress parameters and some liver enzymes were done. The results of this study showed that nZnO at concentration more than 50 mg/kg lead to significant changes in liver enzymes, oxidative stress, liver and renal tissue and sperm quality and quantity. In conclusion, the toxicity of nZnO is more significant when the concentration is increased; however, the use of low doses requires further investigation. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：154 / 160

页数：7

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