Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations?

被引：41

作者：

Braun, Joseph M. ^{[1
]}

Froehlich, Tanya ^{[2
]}

Kalkbrenner, Amy ^{[3
]}

Pfeiffer, Christine M. ^{[4
]}

Fazili, Zia ^{[4
]}

Yolton, Kimberly ^{[2
]}

Lanphear, Bruce P. ^{[5
,6
]}

机构：

[1] Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02912 USA

[2] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

[3] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA

[4] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA

[5] Simon Fraser Univ, Fac Hlth & Sci, Burnaby, BC V5A 1S6, Canada

[6] BC Childrens & Womens Hosp, Child & Family Res Inst, Vancouver, BC V5Z 4H48, Canada

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2014年 / 44卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Autism spectrum disorders; Folate; Pregnancy; Prenatal vitamins; FOLIC-ACID SUPPLEMENTS; TOBACCO-SMOKE EXPOSURE; ONE-CARBON METABOLISM; SPECTRUM DISORDERS; EARLY-PREGNANCY; RISK; REPRODUCIBILITY; QUESTIONNAIRE; ASSOCIATION; VALIDITY;

D O I：

10.1007/s10803-014-2114-x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4-5 years of age in a prospective cohort of 209 mother-child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors.

引用

页码：2602 / 2607

页数：6

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