Synthesis and antibacterial activity of nocathiacin I analogues

被引：47

作者：

Naidu, BN ^{[1
]}

Sorenson, ME ^{[1
]}

Matiskella, JD ^{[1
]}

Li, WY ^{[1
]}

Sausker, JB ^{[1
]}

Zhang, YH ^{[1
]}

Connolly, TP ^{[1
]}

Lam, KS ^{[1
]}

Bronson, JJ ^{[1
]}

Pucci, MJ ^{[1
]}

Yang, H ^{[1
]}

Ueda, Y ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 13期

关键词：

nocathiacin I; antibacterial activity;

D O I：

10.1016/j.bmcl.2006.03.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereoselective reduction of dehydroalanine double bond in nocathiacin 1 afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4-32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3545 / 3549

页数：5

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