Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm

被引：49

作者：

Berker, Moritz ^{[1
]}

Frank, Larissa Johanna ^{[1
]}

Gessner, Anja Lidwina ^{[1
]}

Grassl, Niklas ^{[1
]}

Holtermann, Anne Verena ^{[1
]}

Hoeppner, Stefanie ^{[1
]}

Kraef, Christian ^{[1
]}

Leclaire, Martin Dominik ^{[1
]}

Maier, Pia ^{[1
]}

Messerer, David Alexander Christian ^{[1
]}

Moehrmann, Lino ^{[1
]}

Nieke, Jan Philipp ^{[1
]}

Schoch, Diana ^{[1
]}

Soli, Dominik ^{[1
]}

Woopen, Christina Marianne Paulina ^{[1
]}

机构：

[1] German Acad Scholarship Fdn, Bonn, Germany

来源：

CLINICAL IMMUNOLOGY | 2017年 / 174卷

关键词：

COLONY-STIMULATING FACTOR; THYMIC STROMAL LYMPHOPOIETIN; CSF GENE POLYMORPHISMS; HUMAN EPITHELIAL-CELLS; GROWTH-FACTOR-BETA; INTERFERON-GAMMA; GM-CSF; ATOPIC-DERMATITIS; IFN-GAMMA; TRANSCRIPTION FACTOR;

D O I：

10.1016/j.clim.2016.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergic diseases have emerged as a major health care burden, especially in the western hemisphere. They are defined by overshooting reactions of an aberrant immune system to harmless exogenous stimuli. The T(H)1/T(H)2 paradigm assumes that a dominance of T(H)2 cell activation and an inadequate T(H)1 cell response are responsible for the development of allergies. However, the characterization of additional T helper cell subpopulations such as T(H)9, T(H)17, T(H)22, THGM-CSF and their interplay with regulatory T cells suggest further layers of complexity. This review summarizes state-of-the-art knowledge on T cell diversity and their induction, while revisiting the T(H)1/T(H)2 paradigm. With respect to these numerous contributors, it offers a new perspective on the pathogenesis of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) incorporating recent discoveries in the field of T cell plasticity. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：73 / 83

页数：11

共 181 条

[1] Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease [J].