Etiology of Acute Undifferentiated Febrile Illness in the Amazon Basin of Ecuador

被引：93

作者：

Manock, Stephen R. ^{[2
]}

Jacobsen, Kathryn H. ^{[1
]}

Brito de Bravo, Narcisa ^{[3
]}

Russell, Kevin L. ^{[4
]}

Negrete, Monica ^{[5
]}

Olson, James G.

Sanchez, Jose L. ^{[4
]}

Blair, Patrick J. ^{[6
]}

Smalligan, Roger D. ^{[7
]}

Quist, Brad K. ^{[8
]}

Freire Espin, Juan ^{[9
]}

Espinoza, Willan R. ^{[10
]}

MacCormick, Fiona ^{[11
]}

Fleming, Lila C. ^{[1
]}

Kochel, Tadeusz ^{[12
]}

机构：

[1] George Mason Univ, Dept Global & Community Hlth, Fairfax, VA 22030 USA

[2] Rural Med Serv, Parrottsville, TN 37843 USA

[3] Hosp Vozandes Oriente, Shell, Pastaza, Ecuador

[4] Armed Forces Hlth Surveillance Ctr, Dept Def Global Emerging Surveillance & Response, Silver Spring, MD 20910 USA

[5] I TECH, Maputo, Mozambique

[6] Naval Hlth Res Ctr, San Diego, CA 92106 USA

[7] E Tennessee State Univ, Quillen Coll Med, Johnson City, TN 37604 USA

[8] HCJB Global, Community Dev Dept, Quito, Ecuador

[9] Hosp Gen Fuerzas Armadas, Dept Med Interna, Quito, Ecuador

[10] Policlin Militar San Jorge, Sangolqui, Pichincha, Ecuador

[11] W Cumberland Dist Gen Hosp, N Cumbria Acute Hosp NHS Trust, Whitehaven CA28 8JG, Cumbria, England

[12] US Med Res Ctr Detachment, Lima, Peru

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 81卷 / 01期

关键词：

ACUTE Q-FEVER; DENGUE VIRUS; LEPTOSPIROSIS; DIAGNOSIS; ADULTS; EPIDEMIC; OUTBREAK; EXPOSURE; SPECTRUM; DISEASE;

D O I：

10.4269/ajtmh.2009.81.146

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We conducted a longitudinal observational study of 533 patients presenting to two hospitals in the Ecuadorean Amazon basin with acute undifferentiated febrile illness (AUFI) from 2001 through 2004. Viral isolation, reverse transcription-polymerase chain reaction (RT-PCR), IgM seroconversion, and malaria smears identified pathogens responsible for fever in 122 (40.1%) of 304 patients who provided both acute and convalescent blood samples. Leptospirosis was found in 40 (13.2%), malaria in 38 (12.5%), rickettsioses in 18 (5.9%), dengue fever in 16 (5.3%), Q fever in 1.5 (4.9%), brucellosis in 4 (1.3%), Ilheus infection in 3 (1.0%), and Venezuelan equine encephalitis (VEE), Oropouche, and St. Louis encephalitis virus infections in less than 1% of these patients. Viral isolation and RT-PCR on another 229 participants who provided only acute samples identified 3 cases of dengue fever, 2 of VEE, and 1 of Ilheus. None of these pathogens, except for malaria, had previously been detected in the study area.

引用

页码：146 / 151

页数：6

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