miR-195 Targets HDGF to inhibit proliferation and invasion of NSCLC cells

被引：57

作者：

Guo, Haizhou ^{[1
]}

Li, Weihao ^{[1
]}

Zheng, Tianliang ^{[1
]}

Liu, Zhangsuo ^{[2
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Thorac Surg, Zhengzhou 450000, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Inst Nephrol, Zhengzhou 450000, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 09期

关键词：

NSCLC; miR-195; HDGF; Proliferation; Migration; Invasion; LUNG-CANCER CELLS; PROGNOSTIC-FACTOR; DOWN-REGULATION; GROWTH-FACTOR; TUMOR-GROWTH; MOTILITY; PROMOTES; MICRORNA-195;

D O I：

10.1007/s13277-014-2153-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-small cell lung cancer (NSCLC) is one of the most common causes of cancer-related death worldwide. MicroRNAs (miRNAs) play critical roles in the development and progression of NSCLC. miR-195 acts as a tumor suppressor in several cancers, however, its role in NSCLC is not well understood. Herein, we found that miR-195 was significantly decreased in both NSCLC tissues and cell lines. Forced expression of miR-195 significantly suppressed proliferation, migration, and invasion of NSCLC cells. Hepatoma-derived growth factor (HDGF) was identified as a target of miR-195 in NSCLC cells. Overexpression of HDGF dramatically abolished the tumor suppressive role of miR-195 in NSCLC cells. Our results demonstrated a tumor suppressive role of miR-195 in NSCLC, and suggested a potential therapeutic target for NSCLC.

引用

页码：8861 / 8866

页数：6

共 50 条

[21] LncRNA LINC00473 promoted colorectal cancer cell proliferation and invasion by targeting miR-195 expression
Li, Shilei
Lv, Chunyu
Li, Jun
Xie, Tao
Liu, Xianbin
Zheng, Zhiwei
Qin, Zhaoyang
Hui, Xizeng
Yu, Yang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 13 (06): : 6066 - 6075
[22] miR-125a-3p targets MTA1 to suppress NSCLC cell proliferation, migration, and invasion
Zhang, Hong
Zhu, Xiaoxia
Li, Na
Li, Dianhe
Sha, Zhou
Zheng, Xiaokang
Wang, Haofei
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2015, 47 (07) : 496 - 503
[23] MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's Disease
Lei, Hao
Tang, Junwei
Li, Hongxing
Zhang, Hongwei
Lu, Changgui
Chen, Huan
Li, Wei
Xia, Yankai
Tang, Weibing
BMC GASTROENTEROLOGY, 2014, 14
[24] MicroRNA-212 Targets Mitogen-Activated Protein Kinase 1 to Inhibit Proliferation and Invasion of Prostate Cancer Cells
Hu, Bo
Jin, Xunbo
Wang, Jianbo
ONCOLOGY RESEARCH, 2018, 26 (07) : 1093 - 1102
[25] miR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1
Li, Enqi
Zhang, Jinli
Yuan, Tianxiang
Ma, Baotong
TUMOR BIOLOGY, 2014, 35 (08) : 7645 - 7650
[26] MiR-1-3p suppresses cell proliferation and invasion and targets STC2 in gastric cancer
Ke, J.
Zhang, B-H
Li, Y-Y
Zhong, M.
Ma, W.
Xue, H.
Wen, Y-D
Cai, Y-D
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (20) : 8870 - 8877
[27] miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells
Xie, Xiao
Liu, Hongtao
Wang, Mingsong
Ding, Fangbao
Xiao, Haibo
Hu, Fengqing
Hu, Rui
Mei, Ju
TUMOR BIOLOGY, 2015, 36 (07) : 5031 - 5038
[28] miR-195 inhibits the proliferation and migration of chondrocytes by targeting GIT1
Gu, Yang-Lin
Rong, Xiao-Xu
Wen, Li-Ting
Zhu, Guo-Xing
Qian, Ming-Quan
MOLECULAR MEDICINE REPORTS, 2017, 15 (01) : 194 - 200
[29] MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3
Zhu, Shasha
Kong, Xiangbing
Song, Mengru
Chi, Mingyang
Liu, Yitong
Zhang, Peng
Zhang, Qiao
Shang, Pingping
Feng, Feifei
FRONTIERS IN ONCOLOGY, 2022, 12
[30] MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells
Shi, Bingxia
Ma, Chao
Liu, Guolin
Guo, Yanjun
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, 24 (1)

← 1 2 3 4 5 →