Enantioselection in bilirubin analogs with only one propionic acid group

被引：8
作者：
Boiadjiev, SE [1 ]
Lightner, DA [1 ]
机构：
[1] UNIV NEVADA, DEPT CHEM, RENO, NV 89557 USA
来源：
TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 21期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0957-4166(97)00481-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Enantiopure synthetic bilirubin analogs (1 and 2) with only a single beta-methyl propionic acid group adopt a folded, ridge-tile conformation stabilized by intramolecular hydrogen bonding. The beta-methyl group forces the pigment to adopt a left-handed (M) helical conformation, as evidenced by exciton circular dichroism spectra and indicating that one propionic acid group is sufficient to control the pigment's conformation. (C) 1997 Elsevier Science Ltd.
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收藏
页码：3603 / 3615
页数：13
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