Genus Blepharis (Acanthaceae): A review of ethnomedicinally used species, and their phytochemistry and pharmacological activities

被引：10
作者：
Dirar, Amina Ibrahim [1 ,2 ,3 ]
Adhikari-Devkota, Anjana [1 ]
Kunwar, Ripu Mardhan [4 ]
Paudel, Keshav Raj [5 ,6 ]
Belwal, Tarun [7 ]
Gupta, Gaurav [8 ]
Chellappan, Dinesh Kumar [9 ]
Hansbro, Philip Michael [5 ,6 ,10 ,11 ]
Dua, Kamal [5 ,10 ,11 ,12 ]
Devkota, Hari Prasad [1 ,13 ]
机构：
[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oe Honmachi, Kumamoto, Kumamoto 8620973, Japan
[2] Natl Ctr Res, Med Aromat Plants & Tradit Med Res Inst MAPTRI, POB 2404,Mek Nimr St, Khartoum, Sudan
[3] Natl Univ Sudan, Fac Clin & Ind Pharm, POB 3783, Khartoum, Sudan
[4] Ethnobot Soc Nepal, Kathmandu 44600, Nepal
[5] Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia
[6] Univ Technol Sydney, Fac Sci, Ultimo, NSW 2007, Australia
[7] Zhejiang Univ, Key Lab Agroprod Postharvest Handling, Zhejiang Key Lab Agrofood Proc, Minist Agr & Rural Affairs,Coll Biosyst Engn & Fo, Hangzhou 310058, Peoples R China
[8] Suresh Gyan Vihar Univ, Sch Pharm, Jaipur, Rajasthan, India
[9] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia
[10] Univ Newcastle, HMRI, Prior Res Ctr Hlth Lungs, Callaghan, NSW 2308, Australia
[11] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia
[12] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia
[13] Hlth Life Sci Interdisciplinary & Glocal Oriented, Program Leading Grad Sch, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2021年 / 265卷
关键词：
Blepharis; Acanthaceae; Ethnomedicine; Bioactive compounds; Pharmacology; IN-VITRO ANTIOXIDANT; MEDICINAL-PLANTS; ETHNOPHARMACOLOGICAL SURVEY; C-4; PHOTOSYNTHESIS; AMMANNIA-BACCIFERA; FLAVONOID CONTENTS; LEAF EXTRACTS; MADERASPATENSIS; DISTRICT; CILIARIS;
D O I：
10.1016/j.jep.2020.113255
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ethnopharmacological relevance: Blepharis is an Afro-Asiatic genus belonging to the family Acanthaceae. It comprises about 126 species that occur in arid and semi-arid habitats. Some species of Blepharis are used in traditional medicines in different countries mainly for their anti-inflammatory, wound healing activities along with treatment of gastrointestinal disorders and bone fractures. Aim of the review: The present review aims to collate and analyze the available data and information on distribution, traditional uses, chemical constituents and pharmacological activities of Blepharis. Methods: Scientific information of genus Blepharis was retrieved from the online bibliographic databases such as MEDLINE/PubMed, SciFinder, Web of Science and Google Scholar and secondary resources including books and proceedings. Results: Seven species of Blepharis were found to be reported frequently as useful in folklore in African and Asian countries. B. maderaspatensis was found to be widely used in Indian traditional medicines whereas the B. ciliaris and B. edulis were common in folklore of Egypt, Jordan, and Arabia. Active phytochemicals of Blepharis are flavonoids from B. ciliaris, alkaloids from B. sindica, phenolic acid derivatives, and phytosterols, and derivatives of hydmxamic acids from B. edulis resulted in possessing diverse biological properties such as anti-microbial, anti-inflammatory, and anti-cancer. Conclusions: Various species of Blepharis were found to be used in traditional medicine systems in African and Asian countries. Few of these species were studied for their bioactive chemical constituents however the activity guided isolation studies are not performed. Similarly, detailed pharmacological studies in animal models to explore their mechanism of action are also not reported. Future studies should focus on these aspects related to the medicinally used species of Blepharis. The detailed and comprehensive comparative analysis presented here gives valuable information of the currently used Blepharis species and pave the way to investigate other useful species of Blepharis pertaining to ethnobotany, phytochemistry and discovery of new drugs.
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页数：12
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