Decreased renal expression of vascular endothelial growth factor in lupus nephritis is associated with worse prognosis

被引:44
作者
Avihingsanon, Yingyos [1 ]
Benjachat, Thitima [1 ]
Tassanarong, Adis [2 ]
Sodsai, Pimpayao [1 ]
Kittikovit, Vipawee [1 ,3 ]
Hirankarn, Nattiya [1 ,4 ]
机构
[1] Chulalongkorn Univ, Div Renal, Lupus Res Unit, Dept Med,Fac Med, Bangkok 10330, Thailand
[2] Thammasat Univ, Dept Med, Fac Med, Pathum Thani, Thailand
[3] Chulalongkorn Univ, Dept Pathol, Bangkok 10330, Thailand
[4] Chulalongkorn Univ, Dept Microbiol, Fac Med, Bangkok 10330, Thailand
关键词
biomarker; lupus nephritis; molecular diagnosis; podocyte; VEGF; WT-1; REMNANT KIDNEY MODEL; IMPAIRED ANGIOGENESIS; CONTROLLED-TRIAL; MESSENGER-RNA; ERYTHEMATOSUS; HYPERTENSION; PATHOGENESIS; NEPHROPATHY; ALLOGRAFTS; EFFICACY;
D O I
10.1038/ki.2009.75
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Recent studies suggest that vascular endothelial growth factor ( VEGF) plays a crucial role in the preservation of renal function and may also serve as a useful biomarker in monitoring the progression of lupus nephritis (LN). Here we sought to correlate intrarenal VEGF expression with renal histopathology and prognosis of LN. Biopsy specimens from 35 patients with Class III or IV LN (ISN/RPS categorization) were found to have lower levels of intrarenal VEGF than those found in biopsy tissue taken from 10 donor kidneys sampled at the time of allograft reperfusion. This reduced amount of VEGF mRNA in the patients with LN negatively correlated with glomerular endocapillary proliferation, crescent formation, and a high histologic activity index but was positively associated with increased numbers of urinary podocytes. The level of intrarenal VEGF mRNA accurately predicted the deterioration of renal function in these patients within 12 months. Our study shows that expression of VEGF in renal tissue may serve as a molecular marker of renal damage and may be a predictive factor for short-term loss of kidney function in patients with LN. Kidney International (2009) 75, 1340-1348; doi:10.1038/ki.2009.75; published online 18 March 2009
引用
收藏
页码:1340 / 1348
页数:9
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