Familial spastic paraplegia: Evidence for a fourth locus

被引：6
作者：
Bruyn, RPM
vanVeen, MMM
Kremer, H
Scheltens, PH
Padberg, GW
机构：
[1] UNIV NIJMEGEN HOSP,DEPT HUMAN GENET,NL-6500 HB NIJMEGEN,NETHERLANDS
[2] FREE UNIV AMSTERDAM,DEPT NEUROL,AMSTERDAM,NETHERLANDS
[3] UNIV NIJMEGEN HOSP,DEPT NEUROL,NL-6500 HB NIJMEGEN,NETHERLANDS
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 1997年 / 99卷 / 02期
关键词：
familial spastic paraplegia; genetic linkage; heterogeneity;
D O I：
10.1016/S0303-8467(97)00602-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4). (C) 1997 Elsevier Science B.V.
引用
收藏
页码：87 / 90
页数：4
相关论文
共 18 条
[1]   STRUMPELLS FAMILIAL SPASTIC PARAPLEGIA - GENETICS AND NEUROPATHOLOGY [J].
BEHAN, WMH ;
MAIA, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1974, 37 (01) :8-20
[2]   THE AUTOSOMAL DOMINANT FORM OF PURE FAMILIAL SPASTIC PARAPLEGIA - CLINICAL FINDINGS AND LINKAGE ANALYSIS OF A LARGE PEDIGREE [J].
BOUSTANY, RMN ;
FLEISCHNICK, E ;
ALPER, CA ;
MARAZITA, ML ;
SPENCE, MA ;
MARTIN, JB ;
KOLODNY, EH .
NEUROLOGY, 1987, 37 (06) :910-915
[3]   HEREDITARY SPASTIC PARAPARESIS - CLINICAL AND GENETIC DATA FROM A LARGE DUTCH FAMILY [J].
BRUYN, RPM ;
VANDEUTEKOM, J ;
FRANTS, RR ;
PADBERG, GW .
CLINICAL NEUROLOGY AND NEUROSURGERY, 1993, 95 (02) :125-129
[4]  
BRUYN RPM, 1992, HDB CLIN NEUROLOGY, V59, P301
[5]  
FINK JK, 1995, AM J HUM GENET, V56, P188
[6]  
GISPERT S, 1995, AM J HUM GENET, V56, P183
[7]   THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].
GYAPAY, G ;
MORISSETTE, J ;
VIGNAL, A ;
DIB, C ;
FIZAMES, C ;
MILLASSEAU, P ;
MARC, S ;
BERNARDI, G ;
LATHROP, M ;
WEISSENBACH, J .
NATURE GENETICS, 1994, 7 (02) :246-339
[8]  
Harding A.E., 1984, HEREDITARY ATAXIAS R
[9]   HEREDITARY PURE SPASTIC PARAPLEGIA - A CLINICAL AND GENETIC-STUDY OF 22 FAMILIES [J].
HARDING, AE .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1981, 44 (10) :871-883
[10]   AUTOSOMAL-DOMINANT FAMILIAL SPASTIC PARAPLEGIA IS GENETICALLY HETEROGENEOUS AND ONE LOCUS MAPS TO CHROMOSOME-14Q [J].
HAZAN, J ;
LAMY, C ;
MELKI, J ;
MUNNICH, A ;
DERECONDO, J ;
WEISSENBACH, J .
NATURE GENETICS, 1993, 5 (02) :163-167
12