Two new biologically active cyclopentenones from Dasyseyphus sp A47-98

被引：10

作者：

Mierau, V

Sterner, O

Anke, T

机构：

[1] Lund Univ, Dept Organ & Bioorgan Chem, S-22100 Lund, Sweden

[2] Inst Biotechnol & Wirkstoff Forsch, D-67663 Kaiserslautern, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 05期

关键词：

D O I：

10.7164/antibiotics.57.311

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new biological active cyclopentenones VM 4798-1a (1a) and VM 4798-1b (1b) were obtained as a 3 : 1 inseparable mixture from fermentations of Dasyscyphus sp. A47-98. The mixture of the two isomers showed cytotoxic and weak antibacterial and antifungal properties. VM 4898-1 (2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one, 4), produced by another Dasyscyphus sp. showed no significant biological activity. The structures were elucidated by NMR techniques.

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页码：311 / 315

页数：5

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