Macrophage migration inhibitory factor (MIF), enzymatic activity and the inflammatory response

被引：46

作者：

Cooke, Gordon ^{[1
]}

Armstrong, Michelle E. ^{[1
]}

Donnelly, Seamas C. ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland

来源：

BIOFACTORS | 2009年 / 35卷 / 02期

关键词：

MIF; enzyme; cancer; inflammation; PHENYLPYRUVATE TAUTOMERASE; RHEUMATOID-ARTHRITIS; DISEASE SEVERITY; CYSTIC-FIBROSIS; REGULATORY ROLE; PROTEIN-KINASE; BREAST-CANCER; CYTOKINE; CELLS; ADENOCARCINOMA;

D O I：

10.1002/biof.27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage migration inhibitory factor represents a key cytokine in human diseases. It plays an important role in both innate and acquired immunity and has been shown to be a key mediator of inflammatory diseases. More recently MIF has been,implicated in cancer pathogenesis. Over the decades its structure and functions have been elucidated and this has led to it being further classified as a hormone and an enzyme. It has isomerase enzymatic activity and increasing evidence implicates this activity in inflammatory disease. Consequently, there is increasing interest in developing small molecular weight inhibitors which could target this novel enzymatic activity in disease. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 2, March/April 2009, Pages 165-168 E-mail: seamas.donnelly@ucd.ie

引用

页码：165 / 168

页数：4

共 52 条

[1] Macrophage migration inhibitory factor in hepatocellular carcinoma and liver cirrhosis; relevance to pathogenesis [J].

Akbar, SMF ;

Abe, M ;

Murakami, H ;

Tanimoto, K ;

Kumagi, T ;

Yamashita, Y ;

Michitaka, K ;

Horiike, N ;

Onji, M .

CANCER LETTERS, 2001, 171 (02) :125-132

[2] ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis [J].

Al-Abed, Y ;

Dabideen, D ;

Aljabari, B ;

Valster, A ;

Messmer, D ;

Ochani, M ;

Tanovic, M ;

Ochani, K ;

Bacher, M ;

Nicoletti, F ;

Metz, C ;

Pavlov, VA ;

Miller, EJ ;

Tracey, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (44) :36541-36544

[3] Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism [J].

Armstrong, Michelle E. ;

Gantier, Michael ;

Li, Lili ;

Chung, Wen Y. ;

McCann, Amanda ;

Baugh, John A. ;

Donnelly, Seamas C. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (11) :7125-7133

[4] An essential regulatory role for macrophage migration inhibitory factor in T-cell activation [J].

Bacher, M ;

Metz, CN ;

Calandra, T ;

Mayer, K ;

Chesney, J ;

Lohoff, M ;

Gemsa, D ;

Donnelly, T ;

Bucala, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7849-7854

[5] A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis [J].

Baugh, JA ;

Chitnis, S ;

Donnelly, SC ;

Monteiro, J ;

Lin, X ;

Plant, BJ ;

Wolfe, F ;

Gregersen, PK ;

Bucala, R .

GENES AND IMMUNITY, 2002, 3 (03) :170-176

[6] Macrophage migration inhibitory factor [J].

Baugh, JA ;

Bucala, R .

CRITICAL CARE MEDICINE, 2002, 30 (01) :S27-S35

[7] Biochemical and nutational investigations of the enzymatic activity of macrophage migration inhibitory factor [J].

Bendrat, K ;

AlAbed, Y ;

Callaway, DJE ;

Peng, T ;

Calandra, T ;

Metz, CN ;

Bucala, R .

BIOCHEMISTRY, 1997, 36 (49) :15356-15362

[8] MIF IS A PITUITARY-DERIVED CYTOKINE THAT POTENTIATES LETHAL ENDOTOXEMIA [J].

BERNHAGEN, J ;

CALANDRA, T ;

MITCHELL, RA ;

MARTIN, SB ;

TRACEY, KJ ;

VOELTER, W ;

MANOGUE, KR ;

CERAMI, A ;

BUCALA, R .

NATURE, 1993, 365 (6448) :756-759

[9] Production of macrophage migration inhibitory factor by human and murine neuroblastoma [J].

Bin, Q ;

Johnson, BD ;

Schauer, DW ;

Casper, JT ;

Orentas, RJ .

TUMOR BIOLOGY, 2002, 23 (03) :123-129

[10] Protein expression profiles in human breast ductal carcinoma and histologically normal tissue [J].

Bini, L ;

Magi, B ;

Marzocchi, B ;

Arcuri, F ;

Tripodi, S ;

Cintorino, M ;

Sanchez, JC ;

Frutiger, S ;

Hughes, G ;

Pallini, V ;

Hochstrasser, DF ;

Tosi, P .

ELECTROPHORESIS, 1997, 18 (15) :2832-2841

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