Evaluation of Point-of-care Activated Partial Thromboplastin Time Testing by Comparison to Laboratory-based Assay for Control of Intravenous Heparin

被引:10
作者
Douglas, Alexander D.
Jefferis, Jo
Sharma, Rishi
Parker, Rachel
Handa, Ashok
Chantler, Jonathan
机构
[1] Oxford Radcliffe Hosp NHS Trust, Dept Vasc Surg, Oxford, England
[2] Oxford Radcliffe Hosp NHS Trust, Dept Haematol, Oxford, England
[3] Oxford Radcliffe Hosp NHS Trust, Dept Intens Care, Oxford, England
关键词
heparin; APTT; Hemochron; point-of-care;
D O I
10.1177/0003319709332958
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Introduction: Patients on intravenous heparin require regular activated partial thromboplastin time monitoring. Laboratory-based activated partial thromboplastin time assays necessitate a delay between blood sampling and dose adjustment. Point-of-care testing could permit immediate dose adjustments, potentially enabling tighter control of anticoagulation. Aim: To assess equivalence of activated partial thromboplastin time measured by conventional laboratory assay and by a novel proprietary point-of-care testing System (Hemochron Response, ITC, Thoratec Corporation, Edison, NJ) among surgical ward patients on intravenous heparin. Methods: A total of 39 blood samples from patients on intravenous heparin were tested with both laboratory and point-of-care assays. Assay equivalence was assessed by Bland-Altman analysis. Results. Point-of-care measurements exceeded laboratory activated partial thromboplastin time by a mean of 15 seconds (standard deviation 19). In 19 cases (49%), the point-of-care measurement would have resulted in different heparin dosing from the laboratory activated partial thromboplastin time. Conclusions: The Hemochron Response system is not Sufficiently accurate for routine ward use compared with laboratory activated partial thromboplastin time assays.
引用
收藏
页码:358 / 361
页数:4
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