DNA vaccines: safety and efficacy issues

被引：65
作者：
Klinman, DM
Takeno, M
Ichino, M
Gu, ML
Yamshchikov, G
Mor, G
Conover, J
机构：
[1] Section of Retroviral Immunology, Division of Viral Products, Bldg. 29A, Bethesda
来源：
SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 1997年 / 19卷 / 02期
关键词：
D O I：
10.1007/BF00870272
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
DNA technology has been harnessed to produce a variety of plasmid-based vaccines designed to prevent viral, bacterial and parasitic infections. The rapid adoption and implementation of this novel vaccine strategy carries with it important safety and efficacy concerns. This review will focus on whether DNA vaccines (1) are likely to induce systemic or organ-specific autoimmune disease, (2) have the potential to induce tolerance rather than immunity, and (3) are as effective in individuals with depressed immune function as they are in healthy adults.
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收藏
页码：245 / 256
页数：12
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