Therapeutic Potential of HO-1 in Autoimmune Diseases

被引：28
作者：
Li, Bao-Zhu [1 ,2 ]
Guo, Biao [3 ]
Zhang, Hai-Yan [4 ]
Liu, Juan [1 ,2 ]
Tao, Sha-Sha [1 ,2 ]
Pan, Hai-Feng [1 ,2 ]
Ye, Dong-Qing [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Anhui Prov Lab Populat Hlth & Major Dis Screening, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Sch Hlth Serv Management, Hefei 230032, Anhui, Peoples R China
[4] Anhui Med Univ, Sch Publ Hlth, Dept Hyg Anal & Detect, Hefei 230032, Anhui, Peoples R China
来源：
INFLAMMATION | 2014年 / 37卷 / 05期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
heme oxygenase-1; carbon monoxide; autoimmune diseases; anti-inflammation; immunomodulation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HEME OXYGENASE-1 EXPRESSION; REGULATORY T-CELLS; COLLAGEN-INDUCED ARTHRITIS; CARBON-MONOXIDE; RHEUMATOID-ARTHRITIS; PROTECTIVE ROLE; INFLAMMATORY RESPONSES; AIRWAY INFLAMMATION; MULTIPLE-SCLEROSIS;
D O I：
10.1007/s10753-014-9908-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule. Recent studies have clarified its significant functions in many diseases with substantial findings. In autoimmune diseases, HO-1 may have promising therapeutic potential. Here, we briefly reviewed recent advances in this field, aiming at hopefully exploring the potential therapeutic roles of HO-1, and design HO-1-based strategies for the treatment of autoimmune diseases.
引用
收藏
页码：1779 / 1788
页数：10
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