New antiepileptic drugs

被引：2

作者：

Rouvel-Tallec, A. ^{[1
]}

机构：

[1] Hop Delafontaine, Serv Explorat Fonctionnelles Neurol, F-93200 St Denis, France

来源：

REVUE DE MEDECINE INTERNE | 2009年 / 30卷 / 04期

关键词：

Epilepsy; Treatment; RANDOMIZED CONTROLLED-TRIAL; EPILEPSY; SANAD; LAMOTRIGINE; TOPIRAMATE; GUIDELINES;

D O I：

10.1016/j.revmed.2008.11.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since 1994, 10 new antiepileptics drugs have been developed and many others will be available in a near future. Effectiveness of theses new antiepileptic drugs is similar to the old ones but they have a better side-effect profile. This article updates their clinical use, taking into account the recent studies. These new antiepileptics drugs improve quality of life of the patients, but their use is not entirely safe, including the possible aggravation of certain forms of epilepsy. A better physiopathological knowledge of the epilepsy will help in the future to choose the most adequate drug(s) for each patient. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：335 / 339

页数：5

共 7 条

[1] Nice guidelines-national institute for clinical excellence [J].

Ben-Menachem, Elinor ;

French, Jacqueline A. .

EPILEPSIA, 2006, 47 :62-64

[2] Progress report on new antiepileptic drugs: A summary of the Eigth Eflat Conference (EILAT VIII) [J].

Bialer, Meir ;

Johannessen, Svein I. ;

Kupferberg, Harvey J. ;

Levy, Rene H. ;

Perucca, Emilio ;

Tomson, Torbjorn .

EPILEPSY RESEARCH, 2007, 73 (01) :1-52

[3] Choosing a first drug treatment for epilepsy after SANAD: Randomized controlled trials, systematic reviews, guidelines and treating patients. [J].

Chadwick, David ;

Marson, Tony .

EPILEPSIA, 2007, 48 (07) :1259-1263

[4] Old versus new antiepileptic drugs: the SANAD study [J].

Hadzic, Nedim ;

Vara, Roshni ;

Raiman, Julian ;

Mieli-Vergani, Giorgina .

LANCET, 2007, 370 (9584) :315-315

[5] The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial [J].

Marson, Anthony G. ;

Al-Kharusi, Asya M. ;

Alwaidh, Muna ;

Appleton, Richard ;

Baker, Gus A. ;

Chadwick, David W. ;

Cramp, Celia ;

Cockerell, Oliver C. ;

Cooper, Paul N. ;

Doughty, Julie ;

Eaton, Barbara ;

Gamble, Carrot ;

Goulding, Peter J. ;

Howell, Stephen J. L. ;

Hughes, Adrian ;

Jackson, Margaret ;

Jacoby, Ann ;

Kellett, Mark ;

Lawson, Geoffrey R. ;

Leach, John Paul ;

Nicolaides, Paola ;

Roberts, Richard ;

Shackley, Phil ;

Shen, Jing ;

Smith, David F. ;

Smith, Philip E. M. ;

Smith, Catrin Tudur ;

Vanoli, Alessandr A. ;

Williamson, Paula R. .

LANCET, 2007, 369 (9566) :1016-1026

[6] The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial [J].