Sclerosis of the peritoneum with encapsulation of the small intestine is one of the most serious complications of continuous ambulatory peritoneal dialysis (CAPD) and is associated with a high mortality rate. Its presence should be suspected in patients treated by CAPD who develop small bowel dysfunction with associated abdominal pain and progressive loss of ultrafiltration. In its severest form, it leads to complete high small intestinal obstruction and requirement for total parenteral nutrition, We report the successful surgical management of two young, severely emaciated patients who had this complication of CAPD, Each had entrapment of their bowel by a thick, fibrosed, and calcified membrane, Both were treated by surgically peeling the membrane away from the intestines. (C) 1997 by the National Kidney Foundation, Inc.