Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors

被引：34

作者：

Zhou, Ying ^{[1
]}

Lin, Feng ^{[1
]}

Chen, Jianfang ^{[1
]}

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 10期

基金：

中国国家自然科学基金;

关键词：

heparin; synthesis; glycosylation; thioglycoside; L-idopyranuronic acid; one pot;

D O I：

10.1016/j.carres.2006.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two fully protected tetrasaccharides, which represent precursors for the synthesis of the regular sequence of heparin, were synthesized via coupling of a pair of disaccharide trichloroacetimidates with a thioglycoside and a glucosamine derivative, respectively, in a sequential manner. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1619 / 1629

页数：11

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