Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors

被引：34
|
作者：
Zhou, Ying [1 ]
Lin, Feng [1 ]
Chen, Jianfang [1 ]
Yu, Biao [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 10期
基金：
中国国家自然科学基金;
关键词：
heparin; synthesis; glycosylation; thioglycoside; L-idopyranuronic acid; one pot;
D O I：
10.1016/j.carres.2006.02.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two fully protected tetrasaccharides, which represent precursors for the synthesis of the regular sequence of heparin, were synthesized via coupling of a pair of disaccharide trichloroacetimidates with a thioglycoside and a glucosamine derivative, respectively, in a sequential manner. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1619 / 1629
页数：11
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