Understanding variability in the BOLD signal and why it matters for aging

被引：140
作者：
Grady, Cheryl L. [1 ,2 ,3 ]
Garrett, Douglas D. [4 ]
机构：
[1] Rotman Res Inst Baycrest, 3560 Bathurst St, Toronto, ON M6A2E1, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[3] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada
[4] Max Planck Soc Univ Coll London Initiat Computat, Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany
来源：
BRAIN IMAGING AND BEHAVIOR | 2014年 / 8卷 / 02期
基金：
加拿大健康研究院;
关键词：
fMRI; BOLD signal; Variability; Aging; Cognition; AGE-RELATED DIFFERENCES; INDIVIDUAL-DIFFERENCES; PHYSIOLOGICAL NOISE; DEFAULT MODE; HUMAN BRAIN; FMRI; DEACTIVATION; PERFORMANCE; COGNITION; PREDICTS;
D O I：
10.1007/s11682-013-9253-0
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
Recent work in neuroscience supports the idea that variability in brain function is necessary for optimal brain responsivity to a changing environment. In this review, we discuss a series of functional magnetic resonance imaging (fMRI) studies in younger and older adults to assess age-related differences in variability of the fMRI signal. This work shows that moment-to-moment brain signal variability represents an important "signal" within what is typically considered measurement-related "noise" in fMRI. This accumulation of evidence suggests that moving beyond the mean will provide a complementary window into aging-related neural processes.
引用
收藏
页码：274 / 283
页数：10
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