Understanding variability in the BOLD signal and why it matters for aging

被引：140

作者：

Grady, Cheryl L. ^{[1
,2
,3
]}

Garrett, Douglas D. ^{[4
]}

机构：

[1] Rotman Res Inst Baycrest, 3560 Bathurst St, Toronto, ON M6A2E1, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[3] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

[4] Max Planck Soc Univ Coll London Initiat Computat, Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany

来源：

BRAIN IMAGING AND BEHAVIOR | 2014年 / 8卷 / 02期

基金：

加拿大健康研究院;

关键词：

fMRI; BOLD signal; Variability; Aging; Cognition; AGE-RELATED DIFFERENCES; INDIVIDUAL-DIFFERENCES; PHYSIOLOGICAL NOISE; DEFAULT MODE; HUMAN BRAIN; FMRI; DEACTIVATION; PERFORMANCE; COGNITION; PREDICTS;

D O I：

10.1007/s11682-013-9253-0

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Recent work in neuroscience supports the idea that variability in brain function is necessary for optimal brain responsivity to a changing environment. In this review, we discuss a series of functional magnetic resonance imaging (fMRI) studies in younger and older adults to assess age-related differences in variability of the fMRI signal. This work shows that moment-to-moment brain signal variability represents an important "signal" within what is typically considered measurement-related "noise" in fMRI. This accumulation of evidence suggests that moving beyond the mean will provide a complementary window into aging-related neural processes.

引用

页码：274 / 283

页数：10

共 57 条

[1] The variability of human, BOLD hemodynamic responses [J].

Aguirre, GK ;

Zarahn, E ;

D'Esposito, M .

NEUROIMAGE, 1998, 8 (04) :360-369

[2] Disruption of large-scale brain systems in advanced aging [J].

Andrews-Hanna, Jessica R. ;

Snyder, Abraham Z. ;

Vincent, Justin L. ;

Lustig, Cindy ;

Head, Denise ;

Raichle, Marcus E. ;

Buckner, Randy L. .

NEURON, 2007, 56 (05) :924-935

[3] The correlative triad among aging, dopamine, and cognition:: Current status and future prospects [J].

Backman, Lars ;

Nyberg, Lars ;

Lindenberger, Ulman ;

Li, Shu-Chen ;

Farde, Lars .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2006, 30 (06) :791-807

[4]

Bandettini Peter A, 2012, Neuroimage, V61, pA3, DOI 10.1016/j.neuroimage.2012.01.130

[5] Probabilistic Population Codes for Bayesian Decision Making [J].

Beck, Jeffrey M. ;

Ma, Wei Ji ;

Kiani, Roozbeh ;

Hanks, Tim ;

Churchland, Anne K. ;

Roitman, Jamie ;

Shadlen, Michael N. ;

Latham, Peter E. ;

Pouget, Alexandre .

NEURON, 2008, 60 (06) :1142-1152

[6] The role of physiological noise in resting-state functional connectivity [J].

Birn, Rasmus M. .

NEUROIMAGE, 2012, 62 (02) :864-870

[7] WHAT KIND OF NOISE INCREASES WITH AGE [J].

CREMER, R ;

ZEEF, EJ .

JOURNALS OF GERONTOLOGY, 1987, 42 (05) :515-518

[8] Alterations in the bold FMRI signal with ageing and disease: A challenge for neuroimaging [J].

D'Esposito, M ;

Deouell, LY ;

Gazzaley, A .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (11) :863-872

[9] Emerging concepts for the dynamical organization of resting-state activity in the brain [J].

Deco, Gustavo ;

Jirsa, Viktor K. ;

McIntosh, Anthony R. .

NATURE REVIEWS NEUROSCIENCE, 2011, 12 (01) :43-56

[10] Key role of coupling, delay, and noise in resting brain fluctuations [J].

Deco, Gustavo ;

Jirsa, Viktor ;

McIntosh, A. R. ;

Sporns, Olaf ;

Koetter, Rolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (25) :10302-10307

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