Hitchhiking without covalent integration

被引：17

作者：

Botchan, M ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Div Biochem & Mol Biol, Berkeley, CA 94720 USA

来源：

CELL | 2004年 / 117卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(04)00410-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotes, many latent viruses attach to mitotic chromosomes noncovalently for effective partitioning in dividing cells. For different viruses, the cis and trans elements encoded by the episomes have been effectively defined but the chromosomal "receptors" for such tethering have remained elusive. In this issue of Cell, You et al. (2004) give us a first insight into the cellular protein machinery important for animal papillomavirus retention.

引用

页码：280 / 281

页数：2

共 8 条

[1]

CAMPBELL AM, 1962, ADV GENET, V11, P101

[2] The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis [J].

Dey, A ;

Chitsaz, F ;

Abbasi, A ;

Misteli, T ;

Ozato, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) :8758-8763

[3] Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4 [J].

Houzelstein, D ;

Bullock, SL ;

Lynch, DE ;

Grigorieva, EF ;

Wilson, VA ;

Beddington, RSP .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (11) :3794-3802

[4]

LWOFF A, 1950, ANN I PASTEUR PARIS, V78, P711

[5] A mammalian bromodomain protein, Brd4, interacts with replication factor C and inhibits progression to S phase [J].

Maruyama, T ;

Farina, A ;

Dey, A ;

Cheong, J ;

Bermudez, VP ;

Tamura, T ;

Sciortino, S ;

Shuman, J ;

Hurwitz, J ;

Ozato, K .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (18) :6509-6520

[6]

Muzyczka N., 2001, Fields Virology, P2327

[7] E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes [J].

Voitenleitner, C ;

Botchan, M .

JOURNAL OF VIROLOGY, 2002, 76 (07) :3440-3451

[8] Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes [J].

You, J ;

Croyle, JL ;

Nishimura, A ;

Ozato, K ;

Howley, PM .

CELL, 2004, 117 (03) :349-360

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