Synthesis and Evaluation of the Cytotoxic Activities of Some Isatin Derivatives

被引：1
作者：
Reddy, Sanapalli Subba [1 ]
Pallela, Ramjee [1 ]
Kim, Dong-Min [1 ]
Won, Mi-Sook [2 ]
Shim, Yoon-Bo [1 ]
机构：
[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea
[2] Busan Ctr, Korea Basic Sci Inst, Pusan 609735, South Korea
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 11期
关键词：
indolo[2,3-b]quinoxaline; indolin-2-one; in vitro cytotoxic activity; N-MANNICH BASES; ANTI-HIV ACTIVITIES; IN-VITRO; ANTIVIRAL ACTIVITY; ANTIBACTERIAL; ANTIFUNGAL; DESIGN; SCHIFF; GROWTH; AGENTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of isatin derivatives, 1-butyl-5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (3a-d), 6-butyl-chloro/fluoro-6H-indolo[2,3-b]quinoxalines (4a-h), and 5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (5a-h) were synthesized and characterized by using Fourier transform (FT)-IR, H-1- and C-13-NMR spectroscopy, mass spectrometric and elemental analysis. The substances were further subjected to in vitro cytotoxicity evaluation against HeLa, SK-BR-3, and MCF-7 cells. The results showed that quinoxalines 4d, 4e, and 4g; and indolin-2-one 5f display significant in vitro cytotoxic activities against HeLa cells and further the compound 4d has resulted in highest cytotoxicity in the entire series studied. In addition, 5f was shown to display substantial activity against all the three cell lines used in the current study.
引用
收藏
页码：1105 / 1113
页数：9
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