Role of the inositol 1,4,5-trisphosphate receptor in early embryonic development

被引:12
作者
Kume, S [1 ]
机构
[1] Japan Sci & Technol Corp, Exploratory Res Adv Technol, Mikoshiba Calciosignal Net Project, Bunkyo Ku, Tokyo 1130021, Japan
关键词
IP3; Ca2+; dorsoventral axis formation; fertilization; development;
D O I
10.1007/s000180050431
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is now considerable literature on the importance of phosphatidylinositol cycle activation in transducing information of various types across the plasma membrane. Though much of the data derives from studies on somatic cells, there is increasing evidence for crucial events related to development, including fertilization, cell cycle progression and dorsoventral axis formation. In this review, focus is directed mainly to the molecular basis of the inositol 1,4,5-triphosphate receptor expressed in oocytes and early embryos of Xenopus. Recent progress in studies concerning the role of this receptor in early embryonic development is discussed.
引用
收藏
页码:296 / 304
页数:9
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