International Union of Pharmacology. LX. Retinoic acid receptors

被引：313

作者：

Germain, Pierre

Chambon, Pierre

Eichele, Gregor

Evans, Ronald M.

Lazar, Mitchell A.

Leid, Mark

De Lera, Angel R.

Lotan, Reuben

Mangelsdorf, David J.

Gronemeyer, Hinrich

机构：

[1] Univ Strasbourg 1, INSERM, Inst Genet & Biol Mol & Cellulaire, CNRS, Illkirch Graffenstaden, France

[2] Max Planck Inst Expt Endocrinol, Hannover, Germany

[3] Salk Inst Biol Studies, Howard Hughes Med Inst, Gene Express Lab, La Jolla, CA 92037 USA

[4] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Dept Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[6] Oregon State Univ, Mol & Cellular Biol Program, Corvallis, OR 97331 USA

[7] Univ Vigo, Fac Quim, Dept Quim Organ, Vigo, Galicia, Spain

[8] Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Unit 432, Houston, TX 77030 USA

[9] Univ Texas, SW Med Ctr, Dept Pharmacol, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

PHARMACOLOGICAL REVIEWS | 2006年 / 58卷 / 04期

关键词：

D O I：

10.1124/pr.58.4.4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors. Copyright © 2006 by The American Society for Pharmacology and Experimental Therapeutics.

引用

页码：712 / 725

页数：14

共 188 条

[1] Region-specific localization of retinoic acid receptor-alpha expression in the rat epididymis
Akmal, KM
Dufour, JM
Kim, KH
[J]. BIOLOGY OF REPRODUCTION, 1996, 54 (05) : 1111 - 1119
[2] RETINOIC ACID RECEPTORS AND RETINOID X-RECEPTORS - INTERACTIONS WITH ENDOGENOUS RETINOIC ACIDS
ALLENBY, G
BOCQUEL, MT
SAUNDERS, M
KAZMER, S
SPECK, J
ROSENBERGER, M
LOVEY, A
KASTNER, P
GRIPPO, JF
CHAMBON, P
LEVIN, AA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) : 30 - 34
[3] Acute myeloid leukemia: Therapeutic impact of epigenetic drugs
Altucci, L
Clarke, N
Nebbioso, A
Scognamiglio, A
Gronemeyer, H
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (09) : 1752 - 1762
[4] The promise of retinoids to fight against cancer
Altucci, L
Gronemeyer, H
[J]. NATURE REVIEWS CANCER, 2001, 1 (03) : 181 - 193
[5] Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL
Altucci, L
Rossin, A
Raffelsberger, W
Reitmair, A
Chomienne, C
Gronemeyer, H
[J]. NATURE MEDICINE, 2001, 7 (06) : 680 - 686
[6] Nuclear hormone receptors and gene expression
Aranda, A
Pascual, A
[J]. PHYSIOLOGICAL REVIEWS, 2001, 81 (03) : 1269 - 1304
[7] Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
Bachman, KE
Park, BH
Rhee, I
Rajagopalan, H
Herman, JG
Baylin, SB
Kinzler, KW
Vogelstein, B
[J]. CANCER CELL, 2003, 3 (01) : 89 - 95
[8] Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J
Rochette-Egly, C
[J]. GENE, 2004, 328 : 1 - 16
[9] TFIIH interacts with the retinoic acid receptor γ and phosphorylates its AF-1-activating domain through cdk7
Bastien, J
Adam-Stitah, S
Riedl, T
Egly, JM
Chambon, P
Rochette-Egly, C
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) : 21896 - 21904
[10] The phosphoinositide 3-kinase/Akt pathway is essential for the retinoic acid-induced differentiation of F9 cells
Bastien, J
Plassat, JL
Payrastre, B
Rochette-Egly, C
[J]. ONCOGENE, 2006, 25 (14) : 2040 - 2047

← 1 2 3 4 5 6 7 8 9 10 →