tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation

被引：67

作者：

Krishna, Srikar ^{[1
,2
]}

Raghavan, Srikala ^{[1
]}

DasGupta, Ramanuj ^{[3
]}

Palakodeti, Dasaradhi ^{[1
]}

机构：

[1] Inst Stem Cell Sci & Regenerat Med, Bangalore, Karnataka, India

[2] SASTRA Univ, Thirumalaisamudram, Thanjavur, India

[3] Genome Inst Singapore, Precis Oncol, Singapore, Singapore

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2021年 / 78卷 / 06期

关键词：

tRNA-derived fragments; tRFs; tsRNA; Post-transcriptional regulation; Small RNAs; Non-coding RNAs; CANCER PROGRESSION; CELL-PROLIFERATION; ANGIOGENIN; STRESS; TRANSLATION; HALVES; IDENTIFICATION; RIBONUCLEASE; METHYLATION; CONTRIBUTE;

D O I：

10.1007/s00018-020-03720-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfer RNA (tRNA)-derived fragments (tRFs) are an emerging class of conserved small non-coding RNAs that play important roles in post-transcriptional gene regulation. High-throughput sequencing of multiple biological samples have identified heterogeneous species of tRFs with distinct functionalities. These small RNAs have garnered a lot of scientific attention due to their ubiquitous expression and versatility in regulating various biological processes. In this review, we highlight our current understanding of tRF biogenesis and their regulatory functions. We summarize the diverse modes of biogenesis through which tRFs are generated and discuss the mechanism through which different tRF species regulate gene expression and the biological implications. Finally, we conceptualize research areas that require focus to strengthen our understanding of the biogenesis and function of tRFs.

引用

页码：2607 / 2619

页数：13

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