MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic

被引：8

作者：

Recio-Vega, Rogelio ^{[1
]}

Angel Dena-Cazares, Jose ^{[1
]}

Luis Ramirez-de la Pena, Jorge ^{[1
]}

Jacobo-Avila, Antonio ^{[2
]}

Portales-Castanedo, Arnulfo ^{[2
]}

Patricia Gallegos-Arreola, Martha ^{[3
]}

Ocampo-Gomez, Guadalupe ^{[1
]}

Michel-Ramirez, Gladis ^{[1
]}

机构：

[1] Univ Coahuila, Sch Med Torreon, Biomed Res Ctr, Dept Environm Hlth, Saltillo, Coahuila, Mexico

[2] Inst Mexicano Seguro Social, Dept Pneumol, Torreon, Coahuila, Mexico

[3] Ctr Invest Biomed Occidente, Div Mol Med, Mol Genet Lab, Guadalajara, Jalisco, Mexico

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2015年 / 56卷 / 09期

关键词：

MRP1; ABCC; lung cancer; arsenic; BAL; MULTIDRUG-RESISTANCE PROTEIN-1; HEAVY-METAL RESISTANCE; BUTHIONINE SULFOXIMINE; ANTIOXIDANT STATUS; DNA METHYLATION; TUMOR-CELLS; GLUTATHIONE; TRANSPORT; GENE; CONJUGATE;

D O I：

10.1002/em.21960

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Alteration of multidrug resistance-associated protein-1 (MRP1) expression has been associated with certain lung diseases, and this protein may be pivotal in protecting the lungs against endogenous or exogenous toxic compounds. The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water. MRP1 expression was assessed in bronchoalveolar cells in a total of 102 participants. MRP1 expression was significantly decreased in those with arsenic urinary levels >50 g/L when compared with the controls. In conclusion, chronic arsenic exposure negatively correlates with the expression of MRP1 in BAL cells in patients with lung cancer. Environ. Mol. Mutagen. 56:759-766, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：759 / 766

页数：8

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