Modern approaches to the design of memory and cognitive enhancers based on AMPA receptor ligands

被引：19
作者：
Grigoriev, V. V. [1 ]
Proshin, A. N. [1 ]
Kinzirsky, A. S. [1 ]
Bachurin, S. O. [1 ]
机构：
[1] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Moscow Region, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2009年 / 78卷 / 05期
关键词：
POSITIVE ALLOSTERIC MODULATORS; GLUTAMATE-OPERATED CHANNELS; ACTIVATED PROTEIN-KINASE; LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; N-ANISOYL-GABA; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; RECOMBINANT AMPA; SYNAPTIC-TRANSMISSION; RODENT MODELS;
D O I：
10.1070/RC2009v078n05ABEH004020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Data on the structure and properties of compounds acting on AMPA receptors, the key subtype of ionotropic glutamate receptors of the mammalian central nervous system, are analyzed. Data on the role of these receptors in provision of memory and cognitive function formation and impairment processes are presented. The attention is focused on the modern views on the mechanisms of AMPA receptor desensitization and deactivation and action of substances affecting these processes. The structures of key positive modulators of AMPA receptors are given. The problems of application of these substances as therapeutic agents for preventing and treating neurodegenerative and psychoneurological diseases are discussed. The bibliography includes 121 references.
引用
收藏
页码：485 / 494
页数：10
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