Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape

被引：47
作者：
Ahmed, Asma [1 ,2 ]
Schmidt, Christian [1 ]
Brunner, Thomas [1 ]
机构：
[1] Univ Konstanz, Dept Biol, Biochem Pharmacol, Constance, Germany
[2] Univ Khartoum, Fac Med, Dept Pharmacol, Khartoum, Sudan
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
关键词：
glucocorticoids; intestinal mucosa; intestinal immune homeostasis; inflammatory bowel disease; colorectal cancer; liver receptor homolog-1; tumor necrosis factor; LIVER RECEPTOR HOMOLOG-1; INFLAMMATORY-BOWEL-DISEASE; DEXTRAN SULFATE SODIUM; COLON-CANCER CELLS; TNF-ALPHA; EPITHELIAL-CELLS; COLORECTAL-CANCER; GENE-EXPRESSION; T-CELLS; ULCERATIVE-COLITIS;
D O I：
10.3389/fimmu.2019.01438
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.
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页数：19
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