Enantioselective Hydrogenation of Racemic α-Arylamino Lactones to Chiral Amino Diols with Site-Specifically Modified Chiral Spiro Iridium Catalysts

被引：21

作者：

Gu, Xue-Song ^{[1
,2
]}

Yu, Na ^{[1
,2
]}

Yang, Xiao-Hui ^{[1
,2
]}

Zhu, An-Te ^{[1
,2
]}

Xie, Jian-Hua ^{[1
,2
]}

Zhou, Qi-Lin ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DYNAMIC KINETIC RESOLUTION; ASYMMETRIC HYDROGENATION; EFFICIENT APPROACH; GROUP LEADS; INHIBITORS; DISCOVERY; KETONES; ESTERS; POTENT;

D O I：

10.1021/acs.orglett.9b01290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for highly enantioselective hydrogenation of racemic alpha-arylamino lactones with catalysis by site-specifically modified chiral Spiro iridium complexes has been developed. With the optimized catalyst, racemic alpha-arylamino-gamma-lactones and alpha-arylamino-delta-lactones could be hydrogenated to the corresponding chiral 2-amino diols with good to excellent enantioselectivities.

引用

页码：4111 / 4115

页数：5

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