UP-REGULATION OF LONG NON-CODING RNA-PCAT-1 PROMOTES INVASION AND METASTASIS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

被引：15

作者：

Razavi, Maryam ^{[1
]}

Ghorbian, Saeid ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Mol Genet, Ahar Branch, Ahar, Iran

来源：

EXCLI JOURNAL | 2019年 / 18卷

关键词：

LncRNA-PCAT-1; esophageal squamous cell carcinoma; ESCC; lncRNA; RNA PCAT-1; CANCER; EXPRESSION; GROWTH; GENE;

D O I：

10.17179/excli2018-1847

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long non-coding RNA prostate cancer associated transcript-1 ncRNA (lncRNA-PCAT-1) plays an important role in the progression of prostate cancer. The present investigation was aimed to evaluate the potential roles of the lncRNA-PCAT-1 gene expression changes in esophageal squamous cell carcinoma (ESCC) between Iranian population. In the case-control investigation, we have analyzed a total of 150 fresh tissue samples, compromising of 75 cancerous tissues and 75 adjacent normal tissues from patients with ESCC. We used quantitative Real-time polymerase chain reaction (qRT-PCR) to evaluate the lncRNA-PCAT-1 gene expression levels in ESCC patients and correlation between the lncRNA-PCAT-1 expression changes and clinical characteristics. Our findings showed that the lncRNA-PCAT-1 gene was up-regulated in cancerous tissues compared with the adjacent non-cancerous tissues (p=0.0016). In addition, the results revealed a significant correlation between up-regulating of lncRNAPCAT-1 and hot liquid drinking (p =0.017). These findings offer the potential roles of lncRNA-PCAT-1 in the pathogenesis of ESCC and may consider as a candidate prognostic biomarker for ESCC in an Iranian population.

引用

页码：422 / 428

页数：7

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