Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

被引：1103

作者：

Acloque, Herve ^{[1
]}

Adams, Meghan S. ^{[2
]}

Fishwick, Katherine ^{[2
]}

Bronner-Fraser, Marianne ^{[2
]}

Angela Nieto, M. ^{[1
]}

机构：

[1] CSIC UMH, Inst Neurociencias, Alacant 03550, Spain

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 06期

关键词：

HELIX TRANSCRIPTION FACTOR; NEURAL CREST INDUCTION; E-CADHERIN; PRIMITIVE STREAK; GENE-EXPRESSION; FACTOR SNAIL; HIRSCHSPRUNG-DISEASE; TARGETED DISRUPTION; FATE SPECIFICATION; TUMOR PROGRESSION;

D O I：

10.1172/JCI38019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.

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收藏

页码：1438 / 1449

页数：12

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