Nitroimidazole-containing compounds and their antibacterial and antitubercular activities

被引：31

作者：

Zhang, Jingyu ^{[1
]}

Ba, Yanyan ^{[1
]}

Wang, Su ^{[1
]}

Yang, Huaixia ^{[1
]}

Hou, Xuehui ^{[2
]}

Xu, Zhi ^{[3
]}

机构：

[1] Henan Univ Chinese Med, Pharm Coll, Zhengzhou 450046, Henan, Peoples R China

[2] Henan Univ Anim Husb & Econ, Fac Sci, Zhengzhou 450046, Henan, Peoples R China

[3] Huanghuai Univ, Coll Chem & Pharmaceut Engn, Zhumadian, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 179卷

关键词：

Nitroimidazole; Antibacterial; Antitubercular; Drug-resistant; Hybrid molecules; Structure-activity relationship; HELICOBACTER-PYLORI ACTIVITY; MICROWAVE-ASSISTED SYNTHESIS; SCHIFFS BASE DERIVATIVES; IN-VITRO; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITIES; MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL ACTIVITY; METRONIDAZOLE DERIVATIVES; ISATIN HYBRIDS;

D O I：

10.1016/j.ejmech.2019.06.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Infections especially tuberculosis caused by various bacteria including mycobacteria result in millions of lives every year, but the control of bacterial infections is challenged by the limitation of effective pharmaceuticals against drug-resistant pathogens. Nitroimidazoles belong to a group of nitroheterocyclic compounds that have broad-spectrum activity against a series of organisms such as mycobacteria, anaerobic Gram-positive and Gram-negative bacteria, and some of them have already been used in clinics or under clinical trials for the treatment of infectious diseases. In this review, we made an overview of the recent advances in nitroimidazole-containing compounds with antibacterial and antitubercular activity in the recent 20 years. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页码：376 / 388

页数：13

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