Regio- and stereoselective ring opening of vinyl epoxides with MgBr2

被引：2

作者：

Du Ha, J ^{[1
]}

Kim, SY ^{[1
]}

Lee, SJ ^{[1
]}

Kang, SK ^{[1
]}

Ahn, JH ^{[1
]}

Kim, SS ^{[1
]}

Choi, JK ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Div Med Sci, Taejon 305600, South Korea

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 31期

关键词：

vinyl epoxide; ring opening; bromohydrin; MgBr2;

D O I：

10.1016/j.tetlet.2004.06.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regio- and stereoselective ring opening of vinyl epoxides has been achieved by the use of Lewis acid, MgBr2, affording bromohydrins in excellent yield, which are readily transformed to azidoalcohol, a key intermediate of several classes of pyrrolizidine and indolizidine alkaloids. The scope and limitations of the reaction are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5969 / 5972

页数：4

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